Role of Lipid-Based and Polymer-Based Non-Viral Vectors in Nucleic Acid Delivery for Next-Generation Gene Therapy

Role of Lipid-Based and Polymer-Based Non-Viral Vectors in Nucleic Acid Delivery for Next-Generation Gene Therapy

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The field of gene therapy has experienced an insurgence of attention for its widespread ability to regulate gene expression by targeting genomic DNA, messenger RNA, microRNA, and short-interfering RNA Cab Body and Replacement Parts for treating malignant and non-malignant disorders.Numerous nucleic acid analogs have been developed to target coding or non-coding sequences of the human genome for gene regulation.However, broader clinical applications of nucleic acid analogs have been limited due to their poor cell or organ-specific delivery.To resolve these issues, non-viral vectors based on nanoparticles, liposomes, and polyplexes have been developed to date.

This review is centered on non-viral vectors mainly comprising of cationic lipids and polymers for nucleic acid-based delivery ELDERBERRY LIQUID for numerous gene therapy-based applications.